Drugs for toothache, metronidazole can be combined with broad-spectrum antibiotics such as cephalosporin, erythromycin, roxithromycin and so on, which can alleviate the patient’s pain. However, taking medication only treats the symptoms but not the root cause of the disease, and can not completely cure the disease, it is recommended that patients go to the dentist for consultation and identify the cause of the disease. If the pain is caused by caries, when the food stimulates the cavity will cause transient pain, only need to remove the decayed material to fill the cavity. If the pain is caused by pulpitis, the patient usually has night pain, hot and cold stimulation pain, and often the affected tooth can not be localized and need to go to the hospital for routine root canal treatment. If the pain is caused by wisdom teeth pericoronitis, it is necessary to first anti-inflammatory and then for the removal of blocked teeth, so it is recommended that patients can go to the hospital as soon as possible to avoid delays in the diagnosis.