Lung nodules with blood vessel penetration do not necessarily require immediate surgery. Lung nodule with blood vessel penetration means that there is a blood vessel passing through the lung nodule, which has a certain malignant tendency and requires further enhanced CT and puncture biopsy to exclude malignant nodule. If the nodule is benign, there is no need for immediate surgery, pay attention to the follow-up, and observe the size and morphological changes of the nodule. If the malignant nodule is diagnosed by pathological biopsy, PET-CT and other tests may be needed to clarify the stage of the tumor, and then surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy will be performed according to the treatment advice of professional doctors. If the lung nodule has blood vessel penetration, it does not mean that it is 100% malignant nodule, we suggest to go to the regular hospital to improve the systematic examination, according to the results of the examination, to clarify the next step of the treatment plan.