Bone metastasis of liver cancer with osteolytic destruction can be recovered by taking bisphosphonate drugs, but most of them will be treated by removing the lesions. Hepatocellular carcinoma is a malignant tumor caused by hepatitis virus, alcohol and other factors, and when it progresses to the late stage, distant metastasis, such as bone metastasis, can lead to bone pain, pathological fracture and other clinical manifestations due to osteolytic destruction. Bisphosphonates such as alendronate and zoledronic acid can be used to inhibit the activity of osteoclasts and thus inhibit bone resorption, which is effective in restoring the damaged bone. In addition, most of the treatments for bone metastasis in this period are radiotherapy, chemotherapy and surgery to remove the lesions. Bone metastasis of liver cancer needs timely consultation and active treatment under the guidance of physicians.