If a woman reaches the age of 40 with amenorrhea, it means that ovarian failure is a normal physiological phenomenon, if amenorrhea occurs before the age of 40, it is premature ovarian failure, and over the age of 40 is the normal age. Before the age of 45 years belongs to early menopause, which is mainly manifested as menopausal symptoms, hot flashes and night sweats, irritability, poor sleep at night, hormone replacement therapy can be applied. If there is no menstruation for more than 1 year after the age of 40, it is menopause, which can be determined by checking the endocrine to see if it is menopause. If the estrogen and progesterone in the blood is very low and the follicle stimulating hormone and luteinizing hormone are very high, more than 60mmol/mL, it indicates menopause.