Rheumatism is a rheumatic disease, and ankylosing spondylitis is one of the rheumatic diseases. Rheumatic diseases are a large group of diseases caused by degenerative, neoplastic, metabolic, immune, infectious and other factors and affect the bones, joints and surrounding soft tissues, with joint pain as the main symptom, ankylosing spondylitis belongs to the seronegative spondyloarthropathies in rheumatic diseases. The treatment of ankylosing spondylitis is based on anti-rheumatic drugs such as infliximab, salazosulfapyridine and non-steroidal anti-inflammatory drugs such as diclofenac, etc. Surgery is needed when necessary. The disease cannot be cured by itself, and patients diagnosed with ankylosing spondylitis should receive relevant treatments in a timely and standardized manner in order to avoid deformity or disability. It is recommended that patients with ankylosing spondylitis go to the rheumatology and immunology department of a regular hospital for detailed consultation and treatment according to the doctor’s instructions, and do not use medication on their own.