Urethral infections in men are generally treated with medications that target the pathogenic bacterial infection. Urethral infection, also known as urethritis, is generally divided into gonococcal urethritis and non-gonococcal urethritis, which is usually accompanied by painful urination and urethral discharge that is slightly yellow or purulent in color. Gonococcal urethritis is transmitted through sexual contact, caused by Neisseria gonorrhoeae infection, treatment, in clinical terms, mainly penicillin antibiotics and cephalosporins are preferred, generally intravenous treatment effect is stronger, such as ceftriaxone infusion treatment for 3 days. Non-gonococcal urethritis, the causative organisms are many, with mycoplasma, chlamydia, etc. It is important to choose sensitive antibiotic treatment according to the different causative organisms. Acute UTIs caused by intestinal bacteria can be treated with levofloxacin anti-infective treatment. Erythromycin antibiotics are preferred for UTIs caused by Mycoplasma or Chlamydia. In summary, men with urethral infection, the first choice to clear the diagnosis, urinary routine, urine culture of the basic examination is necessary, before the urine culture results can empirically use antibiotic treatment, of course, because the urinary system is connected, urethritis secondary to upper urinary tract infection is also common, perfect urinary ultrasound is sometimes required.