Atorvastatin calcium tablets is a statin lipid-lowering drug that can effectively lower cholesterol and LDL. It is widely used clinically in patients with hypercholesterolemia, mixed hyperlipidemia and atherosclerotic cardiovascular disease. The vast majority of people tolerate atorvastatin calcium tablets well, and its side effects are mostly seen in those who receive high doses of statin therapy, and the common ones are: 1. Abnormal liver function: mainly manifested as elevated transaminases, with an incidence of about 0.5%-3.0% in a dose-dependent manner [1]. Patients with elevated serum alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) more than 3 times the upper limit of normal and combined with elevated total bilirubin should have their dose reduced or discontinued. For those whose aminotransferases are elevated within 3 times the upper limit of normal value, they can be observed on the basis of the original dose or dose reduction, and some patients’ aminotransferases can return to normal after such treatment. 2. Related muscle aspects, including: myalgia, myositis and rhabdomyolysis. Patients with muscle discomfort or weakness and progressive elevation of creatine kinase on continuous testing should reduce the dose of atorvastatin or discontinue the drug. 3. There is an increased risk of new-onset diabetes, with an incidence of about 10-12%, which is a statin effect [1]. However, the overall benefit of atorvastatin on cardiovascular disease is much greater than the risk of new diabetes mellitus. 4. It can cause abnormal cognitive function, but it is mostly transient and has a low probability of occurrence. 5. Other: headache, insomnia, depression and gastrointestinal symptoms such as dyspepsia, diarrhea, abdominal pain and nausea. Atorvastatin calcium tablets, as a common drug for lowering cholesterol and LDL, need to pay attention to regular monitoring of liver function and creatine kinase during medication. For specific medication, please refer to the clinical situation and follow the guidance of the doctor’s interview.