The left knee pain has been there for more than a year, but I always thought it was a sprain, and I didn’t pay much attention to it. Three months ago, his left knee was “twisted” again, but conservative treatment was not good, so when he took a film, it turned out to be a fracture and there was a tumor growing in the bone. He heard from a local doctor that Dr. Xiao Yaoguang of Xinhua Hospital in Hubei Province had done a good surgery and had gone to Beijing to study the treatment of bone tumors, so he went to Dr. Xiao for consultation. Dr. Xiao Yaoguang conducted a comprehensive examination on Mr. Li and concluded that Mr. Li had a giant cell tumor of the distal femur with pathological fracture deformity healing, but the final tumor needed further pathological examination after surgery. After careful study and consultation with the patient, Dr. Xiao performed extensive resection of the tumor and tumor-based knee replacement, and the patient was able to get out of bed and walk half a month later. Dr. Xiao Yaoguang said that giant cell tumor of bone is usually found in young people between 20-40 years old and is a benign tumor with malignant tendency. Traditional surgery is treated by scraping and bone grafting, if the standard of total resection in the capsule can be achieved, the recurrence rate after surgery is 30%, and a small amount of lung metastasis occurs, while often the purpose of total resection cannot be achieved during surgery, the recurrence rate will be higher. Nowadays, with extensive resection, the recurrence rate is only 7%, and the number of pulmonary metastases is even lower. The tumor wall of this patient is very thin and close to the joint cavity, so the traditional scraping and bone grafting surgery cannot reach the standard of intracapsular resection; the patient also has pathological fracture and deformity healing, and there is no place for internal fixation to treat the fracture; so wide resection and tumor prosthesis replacement is the best choice. Dr. Xiao Yaoguang reminds all patients that they should go to regular bone tumor professional doctors when they have bone tumor.