Sputum discharge after taking anti-inflammatory drugs for lung nodules may be the result of inflammatory exudates being discharged in the form of sputum, which will decrease as the inflammation is gradually controlled. If the sputum is discharged for a long period of time, it is necessary to carry out lung CT and other examinations to clarify whether there are other pathogenic infections. Lung nodules are confined, round-like shadows of increased density formed in the lungs by various infectious diseases and malignant tumors. There are usually no obvious clinical symptoms, and they are found when patients undergo CT examination. There are many diseases that cause lung nodules, such as tuberculosis, lung abscess, lung cancer, etc. The treatment modality of lung nodules is related to the cause of the disease, and anti-infective and surgical treatments are generally available. Lung nodules with inflammatory changes can be treated with anti-inflammatory drugs. After the use of anti-inflammatory drugs the inflammation in the lungs is relieved and the inflammatory exudate enters the bronchial walls and is discharged by the movement of the cilia in the walls, forming sputum. When the inflammation around the lung nodules is gradually controlled, sputum discharge will become less and less, and the condition will gradually improve. After using anti-inflammatory drugs, if patients with lung nodules keep expelling pus sputum for a long time without any reduction, they can have a chest CT to check the lesions around the lung nodules, as well as sputum cultures and drug sensitivity tests to see if there are any other pathogens infecting the lungs. Doctors should further develop a treatment plan based on the results of the examination and implement individualized treatment. Patients who keep coughing up sputum should seek immediate medical attention to avoid delays.