High thyroglobulin antibody suggests that the patient may have thyroid autoimmune disease, which may affect thyroid function, hyper or hypothyroidism, and may cause goiter, which may compress the trachea in severe cases. Sometimes it may also be non-thyroidal disease, need to consult the endocrinology department in time for examination, clear condition and symptomatic treatment. 1. When thyroglobulin antibody is elevated, it is common in Hashimoto’s thyroiditis. Laboratory tests of thyroid function may cause hyperthyroidism, and if it is not treated in time, hyperthyroidism crisis may occur, which is life-threatening. Hypothyroidism may occur, which in severe cases affects the heart function, nervous system, and leads to goiter, which compresses the trachea and affects breathing. All of this may be life-threatening. 2. Elevated thyroglobulin antibodies are also seen in some rheumatic immune diseases, such as systemic lupus erythematosus, etc. These immune diseases may cause damage to the function of tissues of the body, and in serious cases, it may be life-threatening, and need to be controlled by timely treatment in the Rheumatology and Immunology Department. It is recommended that patients who find high thyroglobulin antibodies should go to regular hospitals for regular treatment.