Thirst after aspirin may be due to the antipyretic effect of the drug, but also due to the salicylic acid reaction, severe irritability and thirst need to stop the drug, and pay attention to contraindications in the use of drugs. 1. Reasons for thirst (1) antipyretic effect: salicylic acid drugs will stimulate the thermoregulatory center, resulting in skin vasodilatation, increased blood flow, increased sweating and heat dissipation, causing dehydration, resulting in thirst. (2) Salicylic acid reaction: Salicylic acid reaction is a toxic reaction to aspirin. Mild salicylic acid reaction will cause excessive sweating, thirst and other manifestations, and the drug must be discontinued and medical attention must be sought. 2. Adverse reactions and contraindications (1) Allergy is prohibited. (2) Coronary artery bypass graft perioperative period, gastrointestinal bleeding perforated ulcer, severe heart failure, etc. are prohibited. (3)Adverse reactions such as nausea, vomiting, asthma, urticaria, etc., need to adjust or stop using the drug and seek medical advice. (4) The use of children with high fever is prone to poisoning, need to be used with caution. (5) Prohibited during pregnancy and lactation. Aspirin needs to be used under the guidance of the clinician, unauthorized use is prohibited.