What to take to replenish blood in severe anemia is mainly two aspects: dietary regimen and medication. Diet is to increase protein, iron, folic acid, vitamin C and other raw materials for blood production food on the basis of a balanced diet. Drug treatment is mainly oral iron, along with vitamin B12 and folic acid supplementation. A. Dietary regimen: 1. supplement iron-rich foods: animal high-iron foods such as beef, animal liver, animal blood products, etc., and plant high-iron foods such as spinach, rape, eggplant, etc.; 2. high protein diet: protein sources are mainly divided into two categories: animal protein, animal offal, lean meat, fish, shrimp, eggs, milk, etc., and plant protein, such as beans and nuts; 3. ensure the supply of folic acid and vitamin C supply: eat more fresh vegetables and fruits, such as kiwi, oranges, tomatoes, etc. The cooking method should be reasonable to reduce vitamin loss; 4, diet is soft and easy to digest: patients with megaloblastic anemia often have tongue inflammation and gastrointestinal disorders, so the diet should be warm and soft and easy to digest. Second, drug treatment: 1, oral iron: common drugs are ferrous sulfate, ferrous fumarate, ferrous gluconate, etc., which can effectively treat severe anemia; 2, supplementation of vitamin B12 and folic acid: for patients with megaloblastic anemia caused by malnutrition, vitamin B12 and folic acid need to be supplemented in a timely manner, and changes in kidney function should be closely observed during the drug intake to avoid thromboembolism.