People who have been taking hormones for a long time are not recommended to be vaccinated while taking hormones, and it is recommended to consider vaccination after their condition has stabilized and the medication has been stopped for a period of time. Common hormonal drugs, such as glucocorticoids, adrenocorticotropic hormone, norepinephrine hormone, etc., are immunosuppressants. Long-term hormone users may experience a decrease in vaccine effectiveness, an increase in adverse reactions, or even an aggravation of their original condition when they are taking medication for a period of time before vaccination. 1. Decrease in vaccine effect. Long-term hormone consumption will inhibit the immune system, affecting the production of antibodies, which may affect the effectiveness of vaccination. 2. Increase in adverse reactions. After vaccination, some people may have mild adverse reactions, such as mild rash and gastrointestinal reactions. People who have been taking hormones for a long time have a reduced immune system resistance, and the incidence of adverse reactions may increase after vaccination. 3. Exacerbation of pre-existing conditions. Some of the vaccines are live attenuated vaccines, which are potentially pathogenic. Patients who have been taking hormones for a long time may aggravate their pre-existing conditions or induce serious diseases if their immune function is low.