The causes of edema in the inner part of the ankle need to be differentiated and diagnosed according to different situations, as follows: 1. Local causes: if edema occurs in the inner part of one side of the ankle, it may be caused by local causes, and the common causes are gouty nodules, trauma, inflammation, allergy, mosquito bite, which need to be examined to be confirmed. If edema occurs on the inside of both ankles, it may be caused by trauma, allergy, atherosclerosis of the lower limbs, or poor function of the venous valves, resulting in blood pooling in the lower limbs and edema. Pay attention to rest, elevate the lower limbs, through the bilateral lower limb vascular ultrasound can help differential diagnosis; 2, systemic causes: caused by bilateral leg or foot ankle edema, common for systemic lesions, such as heart disease, renal disease, rheumatic system diseases in the systemic lupus erythematosus, desiccation syndrome, rheumatoid arthritis, diabetes mellitus, thyroid disease, liver disease, etc., in which the heart disease and kidney disease are more common. Heart disease can easily lead to edema in the lower limb area, which indicates that heart failure may have occurred, and the history of heart disease can be traced back, and the edema can be disappeared or even cured after the treatment of heart disease. Kidney disease in its early stages can cause edema of the ankles and eyelids, and increased foam in the urine. Systematic treatment of kidney disease can make the edema disappear.