The dangers of long-term wrinkle injections include muscle paralysis, allergies, and general discomfort symptoms, among others. The principle of wrinkle injection is to use biological toxin muscle relaxant, commonly botulinum toxin, injected under the skin, inhibit the release of neurotransmitter acetylcholine, blocking the conduction between the nerve and the muscle, inhibit muscle contraction, to achieve the effect of wrinkle. 1. Muscle paralysis: If long-term injection of wrinkle injections, then it can cause muscle paralysis, paralysis and paralysis of the affected muscles, unnatural expression, muscle stiffness, dystonia, eyelid ptosis, asymmetric wrinkle effect and other symptoms. 2. Allergic symptoms: For patients who are allergic to botulinum toxin, the use of wrinkle needles can cause skin flushing, edema, itching and other allergic symptoms, the long-term use of wrinkle needles, can also cause anaphylactic shock (this is a rare case), and even life-threatening. 3. Systemic discomfort symptoms: long-term injection of wrinkle needles can also cause cold-like symptoms, nausea, vomiting, dizziness, weakness and other systemic discomfort symptoms. Generally long-term injection of Botox is more harmful, it is recommended that patients do not inject Botox for a long time, it is best to inject Botox in regular hospitals, under the guidance of the doctor, to minimize the risks and hazards, and to protect the effect.