I. Non-pharmacological treatment of osteoarthritis includes health education for patients, self-training, weight loss, aerobics, joint mobility training, muscle strength training, use of walking aids, wedge walking insoles for knee inversion, occupational therapy and joint protection, aids for daily life, etc. Patients with osteoarthritis of the knee often have reduced quadriceps muscle strength, which was previously thought to be caused by disuse atrophy, but recent foreign studies have concluded that quadriceps muscle atrophy is not entirely caused by osteoarthritis, and that reduced quadriceps muscle strength may be one of the risk factors for osteoarthritis of the knee, and that due to reduced quadriceps muscle strength, the stability of the knee joint is affected and the normal muscle Therefore, it is beneficial for patients with osteoarthritis to strengthen their quadriceps muscle strength and aerobic training. The first of these is the use of non-steroidal analgesic and anti-inflammatory drugs that inhibit the synthesis of cyclooxygenase and prostaglandins to counteract the inflammatory response and relieve joint edema and pain. You can use ibuprofen 200-400mg once, 3 times a day; or aminoglycoside zinc 200mg once, 3 times a day; nimesulide 100mg once, 2 times a day for 4-6 weeks. 2.Glucosamine is the most important monosaccharide that constitutes polyglucosamine (GS) and proteoglycan in articular cartilage matrix. Normal people can synthesize GS by amination of glucose, but in osteoarthritis, the synthesis of GS in chondrocytes is blocked or insufficient, resulting in softening of cartilage matrix and loss of elasticity, destruction of collagen fiber structure, and increase of cartilage surface lumen to make bones worn and destroyed. Glucosamine can block the pathogenesis of osteoarthritis, promote the synthesis of proteoglycans with normal structure in chondrocytes, and inhibit the production of enzymes (such as collagenase and phospholipase A2) that damage tissue and cartilage, reduce damage to chondrocytes, improve joint movement, relieve joint pain, and delay the course of osteoarthritis. Oral 250-500mg once, 3 times a day, best taken with meals. 3.Sodium hyaluronate is the main component of the synovial fluid of joint cavity and one of the components of cartilage matrix, which plays a lubricating role in joints and reduces friction between tissues. Intra-articular injection can significantly improve the inflammatory response of synovial tissue, enhance the viscosity and lubricating function of joint fluid, protect joint cartilage, promote the healing and regeneration of joint cartilage, relieve pain and increase the mobility of joints. It is often injected intra-articularly, 25mg once, once a week for 5 weeks, and must be operated strictly aseptically. Third, the osteoarthritis surgery treatment osteoarthritis symptoms are very serious, drug treatment is ineffective, and affect the patient’s daily life, you should consider surgical intervention. For osteoarthritis of the knee, some people advocate arthroscopic arthroscopic debridement first, which has certain efficacy for some patients in the near future, but the long-term effect is not certain. 2, artificial joint replacement surgery for most patients with osteoarthritis, femoral head necrosis, rheumatoid arthritis, in the relief of pain, restoration of joint function has significant results, but because of joint replacement surgery there are certain recent and long-term complications, such as loosening and wear of components, osteolysis. Therefore, it is important to strictly control the indications for joint replacement surgery.