Urine microalbumin 35.4mg/L is generally not serious, but whether it is serious or not depends mainly on its etiology and cannot be generalized. Physiological causes of urinary protein is usually not serious; pathologic causes of urinary protein without timely standardized intervention and treatment may appear disease progression, serious cases can be life-threatening, this is more serious. Under normal circumstances, urine microalbumin is less than 20mg / L, when the patient test results for 35.4mg / L, belong to the mildly elevated. Proteinuria can be divided into physiologic proteinuria and pathologic proteinuria according to its nature. Physiological proteinuria is more common in the case of strenuous exercise, fever, etc., the patient’s kidneys have no organic lesions, without special treatment, after resting, the urine protein can usually turn negative, usually does not appear more serious. Pathological proteinuria is usually caused by organic lesions of the kidneys, and its common causes are glomerulonephritis, urinary tract infection, urinary stones and so on. If the primary disease is not timely and standardized treatment, it may cause the progression of the primary disease, which in turn aggravates proteinuria, the gradual decline in renal function, and in severe cases, may even lead to uremia, which is more serious at this time. If the patient’s urine test found elevated microalbumin, it is recommended to go to the regular hospital in time to improve the examination to clarify the cause of the disease, under the guidance of the doctor to targeted treatment or treatment.