Pneumonia caused by multiple myeloma is caused by repeated infection, and should be actively anti-infection treatment, such as intravenous use of immunoglobulin, levofloxacin and so on. Multiple myeloma due to the normal polyclonal immunoglobulin and neutrophil reduction, immunity decline, prone to a variety of infections, such as complication of pneumonia, is a common cause of death, should be a good corresponding disease prevention and treatment. Including chemotherapy, anti-infection and keep the air clean. 1. Anti-infection prophylaxis should be given 3 months after the start of chemotherapy or after transplantation to reduce the risk of infection and avoid complication of pneumonia. Commonly used regimens include bortezomib + dexamethasone, bortezomib + adriamycin + dexamethasone. If a high-dose dexamethasone regimen is used, Pneumocystis carinii and fungal infections should be prevented with drugs such as voriconazole and sulfa. Acyclovir is recommended for the prevention of herpes zoster in patients treated with bortezomib. 2. Intravenous immunoglobulin may be considered if recurrent infections occur or life-threatening infections develop. 3. Disinfect indoor air daily with ultraviolet light, keep the mouth and perineum clean, and keep bowel movements clear. If multiple myeloma disease is diagnosed, early and standardized treatment is recommended to reduce the adverse effects of the disease. All the above medications should be used under doctor’s guidance, avoid self-medication.