Jaundice and malaise after a PD1 immunization shot may be due to liver impairment caused by this shot, or it may be an exacerbation of the progression of the original disease. Immune-associated hepatitis occurs during PD1 use, so patients may experience jaundice as well as malaise. The drug insert states that the incidence of abnormal liver function is approximately 6.7%. If liver function abnormalities occur, they can be treated with additional hepatoprotective drugs (e.g., polyenophosphatidylcholine, etc.), and if they are more severe, PD1 should be discontinued in a timely manner. The use of PD1 may also occur cholestasis, cholestasis is easy to cause bilirubin increase, the patient will show jaundice, itchy skin and some other symptoms. PD1 is an anti-tumor class of immune drugs, the use of jaundice, fatigue and other symptoms, may also be the progress of their own primary disease aggravation. The side effects of the drug are relatively large, the use of the relevant informed consent before signing, the emergence of adverse reactions should be timely detection and timely consultation, it is recommended to use under the guidance of a specialist.