The causes of frequent hiccups are both physiological and pathological. Physiological causes include irregular diet, eating cold food, eating spicy food, etc. Pathological causes include reflux esophagitis, esophageal cancer, mediastinal tumors, etc. Hiccups are mostly caused by spasm of diaphragm, which can be seen in the case of diaphragm compression or stimulation. 1. Physiological causes: such as irregular diet, eating spicy food, etc., which can lead to diaphragm stimulation and diaphragm spasm. 2. Pathological causes: such as reflux esophagitis, gastric reflux stimulates the esophageal wall, which in turn affects the diaphragm, and patients often have symptoms such as acid reflux, heartburn and burning sensation behind the sternum, etc.; such as esophageal cancer and mediastinal tumors, etc., the enlargement of the mass can lead to diaphragm spasm due to diaphragm compression, and esophageal cancer patients can have hoarse voice and difficulty in swallowing, and mediastinal tumors patients can have symptoms such as chest tightness, chest pain and dyspnea. For hiccups, it is recommended to consult a doctor to analyze the cause of hiccups in the light of personal situation and follow the doctor’s instruction for treatment.