The main risk of high ApoE is the possibility of hypertension, coronary heart disease and cerebrovascular disease. Modern medical research shows that high ApoE can have serious effects on the body, such as causing hypertension, increasing the risk of coronary heart disease and the incidence of cerebrovascular disease, because ApoE causes changes in the endothelium of blood vessels, leading to atherosclerosis. Some studies have shown that the majority of patients with atherosclerosis have high levels of ApoE. Therefore, patients with high apolipoprotein E must be taken seriously and treated in a timely manner, such as exercising more and taking medication if necessary.