Heredity, diet, hematologic disorders, renal diseases, drugs and other factors can cause uric acid metabolism disorders. 1. Heredity: inborn deficiency of enzymes related to uric acid metabolism may lead to uric acid metabolism disorders, such as type I glycogen accumulation disease, familial juvenile hyperuricemic nephropathy, increased activity of ribulose phosphate pyrophosphate synthetase, and hypoxanthine-guanine phosphoribosyltransferase defects. 2. Diet: Most of the excess uric acid production is caused by high purine diet, such as eating a lot of meat, animal offal, seafood, etc., and high sugar diet, drinking a lot of alcohol. 3. Blood system diseases: hemolytic anemia, acute and chronic leukemia, multiple myeloma and other blood system diseases can also lead to excessive production of uric acid due to cellular decomposition, causing metabolic disorders. 4. Kidney disease: renal tubular disease, renal insufficiency and other kidney diseases can cause uric acid excretion obstacles and lead to uric acid excretion disorders, resulting in metabolic disorders. 5. Drugs: Furosemide, hydrochlorothiazide, tobacco acid, aspirin and other drugs can also cause uric acid metabolism disorder. If you suspect that uric acid metabolism disorder occurs in the above situations, it is recommended that you go to the endocrinology department and rheumatology department of regular hospitals to have relevant consultation in a timely manner.