Limb-girdle muscular dystrophy can be paralyzing. It is a muscle degeneration disease caused by an inherited gene mutation, clinically characterized by slowly progressive symmetrical muscle weakness and atrophy, which may progress to paralysis without sensory impairment, and is a relatively rare and chronic disease in clinical practice. The disease has a significant impact on the patient’s quality of life and may also be fatal due to serious complications such as pulmonary infection and cardiopulmonary failure. The disease is inherited in an autosomal recessive or dominant pattern, and there are many cases of disseminated disease. Patients with recessive inheritance are more common, more symptomatic, and have an earlier onset of the disease than those with dominant inheritance, with most cases starting between the ages of 10 and 20. The disease usually starts in the shoulder and hip muscles, with difficulty in walking up and down stairs, lifting heavy objects, getting up from a chair, and falling. It can also affect the lower limbs and neck. Although the etiology and pathogenesis of the disease have been studied, there is no specific treatment.