Sulfonylurea hypoglycemic agents are commonly used in clinical practice as oral hypoglycemic agents. The commonly used sulfonylurea hypoglycemic agents include glibenclamide, gliclazide, glipizide, glimepiride, etc. Sulfonylurea hypoglycemic drugs are insulinotropic agents, which work by promoting the secretion of insulin. Therefore, sulfonylurea hypoglycemic drugs are only suitable for patients with type 2 diabetes whose pancreatic beta cells still have some function, and not for patients with type 1 diabetes. Sulfonylurea glucose-lowering drugs can be used in combination with various oral glucose-lowering drugs such as biguanide preparations, glycosidase inhibitors, insulin sensitizers, DPP-4 inhibitors, etc. Sulfonylurea glucose-lowering drugs work by promoting insulin secretion, so the biggest side effect is hypoglycemia, especially in middle-aged and elderly patients, which is likely to occur. Therefore, diabetic patients taking sulfonylureas must pay attention to regular review of blood glucose and regular feeding to avoid serious hypoglycemia.