Carpal tunnel syndrome is a painful and sensory numbness in the thumb, index, and middle fingers due to compression of the median nerve. Initially, it is often characterized by sensory dysfunction in the fingers, and often results in waking up with numbness or burning pain a few hours after going to sleep, which is relieved by activity. So, what are the causes of the symptoms of numbness or burning pain in the fingers after sleep? The following are the causes of numbness or burning pain in the fingers after sleeping and waking up symptoms: 1, local factors (1) factors causing a reduction in the volume of the carpal tunnel: such as Colles fracture, Smith fracture, navicular fracture and dislocation of the lunate bone after the deformity of the healing, as well as acromegaly, and so on. (2) Factors causing increase in the content of carpal tunnel: such as lipoma, fibroma, tendon sheath cysts, abnormal position of the muscles in the carpal tunnel (the superficial flexor muscle belly is too low, the earthworm muscle belly is too high), non-specific synovitis, hematoma. 2.Systemic factors (1)Factors causing neurodegeneration: such as diabetes mellitus, alcoholism, infection, gout and so on. (2) Factors that change fluid balance: such as pregnancy, oral contraceptives, long-term hemodialysis, hypothyroidism. (3) Postural factors: excessive wrist labor, such as computer operators, walking with crutches for the disabled, repeated flexion and extension of the fingers and wrist joints. 77 cases of paraplegic paraplegia patients surveyed by Gellman et al. found that 38 of them (49%) suffered from carpal tunnel syndrome. It should be noted, however, that the etiology of carpal tunnel syndrome in some of these patients is unclear. Pathogenesis The carpal tunnel is a bony fibrous canal formed by the carpal tunnel and the transverse carpal ligament that bridges it. The carpal tunnel consists of the navicular bone and most of the greater trochanter on the radial side; the pea bone and hook bone on the ulnar side; the capitate, navicular, lunate, and lesser trochanter on the dorsal side; and the transverse carpal ligament on the metacarpal side. The transverse carpal ligament is attached to the pea bone and hook bone groove on the ulnar side, and to the navicular tuberosity and the apex of the greater trochanter on the radial side. The transverse carpal ligament is tough, nearly trapezoidal in shape, the size of a small postage stamp (about 2 cm × 2 cm), 1 to 2 mm thick in general, continuing distally with the palmaris tendinae, and proximally with the palmaris lateralis ligament of the wrist (the deep fascia of the forearm), which is positioned about the level of the proximal carpal bone and the base of the metacarpal bone. The carpal tunnel is slightly oval in cross section, with its apex on the radial side. There are 9 flexor tendons and 1 nerve (i.e. median nerve) passing through the carpal tunnel, and the ratio of the area of the carpal tunnel to the sum of the area of the 9 flexor tendons and 1 nerve is about 3:1, thus the area of the carpal tunnel provides a certain amount of space for the activities of the contents of the carpal tunnel.The 9 tendons are arranged in two layers, superficial for the superficial flexor tendons of the finger, which are overlapped in turn from the little finger to the forefinger, and deep for the deep flexor tendons of the finger, which are overlapped in turn from the radial to the ulnar side. The deeper layer is the deep flexor tendon of the finger, which overlaps from radial to ulnar. They are encircled by two tendon bursae, the radial and ulnar bursae, and the flexor digitorum longus tendon is located on the radial side of the superficial layer in a relatively constant position. The median nerve is located in the superficial surface of the superficial flexor tendon (mostly located in the superficial surface of the superficial flexor tendon of the middle finger and ring finger), and its position is relatively constant. The median nerve is always in direct contact with the transverse carpal ligament, and this specific local anatomical relationship is coupled with the fact that the transverse carpal ligament is a relatively tough fibrous tissue, with few elastic fibers, so that the degeneration of the transverse carpal ligament caused by any reason will cause friction and compression of the median nerve, especially during dorsal extension of the wrist, and this is more obvious. This is especially obvious in the case of dorsal extension of the wrist. The vast majority (about 95%) of the median nerve is divided into two branches at the distal edge of the transverse carpal ligament, the lateral branch sends out a return branch to innervate the bunion short spreading muscle, the bunion to the palm muscle and the bunion short flexor muscle (superficial head), and the terminal branch is the first finger palmar general nerve, which is divided into three branches of the finger palmar intrinsic nerve at the end, which are distributed in the skin of the radial and ulnar side of the thumb and radial side margin of the forefinger respectively, and there is a branch of the intrinsic nerve to the radial margin of the forefinger to the first earthworm muscle; the medial branch is divided into the first finger palmar common nerve; the medial branch is divided into the first finger palmar intrinsic nerve, which is distributed in the radial and ulnar side of the thumb and the radial margin of the index finger. The medial branch was divided into the 2nd and 3rd common palmar nerves to the proximal side of the metacarpophalangeal joint, and each of them was divided into 2 common palmar nerves, which were distributed in the skin of the index finger, the middle finger, and the relative margins of the middle finger and the ring finger, and the 2nd common palmar nerve was also branched to the 2nd earthworm muscle. As a result, corresponding sensory-motor deficits occur after median nerve entrapment.