Gonorrhea can occur at any age, but mostly occurs in sexually active young and middle-aged people. The incubation period is usually 2~10 days, with an average of 3~5 days, and patients with incubation period are infectious. Clinical manifestations 1, simple gonorrhea (1) gonococcal urethritis: early symptoms include frequent urination, urgent urination, painful urination, redness and swelling of the urethral orifice with thin mucus outflow soon, the condition worsens after 24 hours, the discharge becomes yellow purulent, and the amount increases. There may be symptoms of urethral irritation, sometimes accompanied by inguinal lymphadenitis. If the foreskin is too long, it can cause prepuceitis and glansitis; when the posterior urethra is involved, there can be hematuria, hematospermia, mild perineal swelling, etc. There is often painful penile erection at night. (2) Gonococcal cervicitis: The main sites of infection in women are the endocervical lining and urethra. 70% of female patients have no symptoms or mild symptoms. The most common symptoms are increased vaginal discharge, painful urination, non-menstrual uterine bleeding, and excessive menstrual bleeding. Physical examination reveals redness, tenderness, and purulent discharge at the cervical orifice; gonococcal urethritis and paraurethral adenitis present with redness and swelling at the urethral orifice, with pressure pain and purulent discharge. Gonococcal vestibular adenitis is characterized by unilateral redness and pain of the vestibular gland and, in severe cases, the formation of abscesses, systemic symptoms and fever. Gonorrhea in girls is usually contracted by close contact with parents who have gonorrhea and by sharing bathroom utensils. (3) Gonorrheal anorectalitis: mainly seen in male homosexuals, women can be directly infected by the secretions of gonorrheal cervicitis in the anorectum. In mild cases, there is only anal itching and burning sensation and discharge of mucus and purulent secretions, while in severe cases, a large amount of purulent and bloody secretions may be discharged. (4) Gonococcal pharyngitis: mostly seen in oral sex. About 80% of people with pharyngeal gonococcal infection are asymptomatic and may present with mild pharyngitis or tonsillitis, occasionally with fever and enlarged cervical lymph nodes, with dry throat, sore throat and painful swallowing. (5) Gonococcal conjunctivitis: Adults are mostly infected by self-inoculation or contact with objects contaminated by secretions, mostly unilateral; newborns are mostly infected by the mother’s birth canal, mostly bilateral. It is characterized by congestion and edema of the conjunctiva, more purulent secretions, and in severe cases, ulceration of the cornea, causing perforation and even blindness. 2, gonorrhea complications male gonococcal urethritis patients due to improper treatment or alcohol abuse, sexual intercourse and other effects, resulting in the further development of infection and spread to the posterior urethra, causing posterior urethritis, prostatitis, vesiculitis, epididymitis, etc.; inflammation after repeated episodes of scar formation can cause urethral stricture, part of the occurrence of vas deferens stricture or obstruction, can also lead to infertility. (1) gonococcal prostatitis: acute cases have fever, frequent urination and pain in the perineum, if not treated in time can form abscesses; chronic patients generally have no obvious symptoms, may have morning urethral discharge and discomfort in the perineum. (2) Gonococcal vesiculitis: acute patients have fever, frequent urination, painful urination, cloudy urine with blood; chronic patients usually have no obvious symptoms, and hardened seminal vesicles can be palpated on rectal finger examination. (3) Gonorrheal epididymitis: mostly unilateral, with fever, scrotal redness, pain, reflex pain in the ipsilateral groin and lower abdomen, and often cloudy urine. The main complication of gonorrhea in women is gonorrheal pelvic inflammatory disease (including acute tubal inflammation, endometritis, secondary tubo-ovarian abscess and pelvic abscess due to rupture, peritonitis, etc.). Repeated attacks can cause tubal stenosis or occlusion, which can lead to ectopic pregnancy, infertility or chronic lower abdominal pain. The gonococcus can spread throughout the body through blood vessels and lymphatic vessels, and bacteremia can occur, which is serious and life-threatening if not treated in time. Clinical manifestations include fever, chills, general malaise, and often lesions near the joints of the extremities, which start as erythema and later develop into pustules, hemorrhagic blisters or central necrosis, scattered distribution, often in small numbers; arthritis, tenosynovitis, endocarditis, pericarditis, pleurisy and pneumonia may also occur.