Age-related macular degeneration is a common blinding eye disease in developed regions over the age of 50. With the aging of the society, the incidence increases and the exact etiology is not clear. It may be related to long-term photodamage to the macula, genetic, metabolic, nutritional, and environmental influences. It is divided into two types: 1. dry (atrophic, non-neovascular) Clinical manifestations start slowly, with unconscious vision loss, visual distortion, and similar degree in both eyes. The main problem is the gradual atrophy and degeneration of the retinal pigment epithelium, Bruch’s membrane, choroidal capillaries and other layers. In the early stage, yellowish-white garden-type vitreous warts of different sizes appear in the posterior part of the fundus, which may fuse, and pigment epithelium proliferates or atrophies, further manifesting as pigment loss, disorder or map-like awe areas. 2. Wet (exudative, neovascular) Clinical manifestations include sudden loss of vision, distortion of visual objects or central dark spot. The other eye may show symptoms only after a longer period of time. The cause is damage to the bruch membrane caused by vitreous warts, etc., which induces the choroidal capillaries to grow neovascularization to the outer layer, i.e., CNV, which is accompanied by fibroblast proliferation and can destroy choroidal capillaries, bruch membrane, pigment epithelial cells and photoreceptor cells, causing severe vision loss. The fundus shows grayish-yellow CNV in the posterior pole with dark red subretinal hemorrhage, which often obscures the CNV, with small lesions less than 1 optic disc in diameter and larger hemorrhages throughout the posterior pole. There is complete loss of central vision. Treatment】 Dry No therapeutic significance. Exudative treatment 1.Laser Laser coagulation of the neovascular membrane located 500μm away from the central macular recess is feasible to prevent further development, but it can recur. 2.Surgery In recent years, vitreous surgery has been used to remove the subretinal neovascular membrane (CNV), but postoperative visual acuity has failed to improve, and the complications of surgery have increased significantly. 3. Photodynamic therapy uses specific binding with CNV endothelial cells, activated by light to produce photo-oxidation reaction and kill endothelial cells, thus achieving the effect of destroying CNV. 4, transsupillary thermotherapy with 810nm laser, closed choroidal neovascular membrane. pDT , TTT is the current hot spot of treatment research, the efficacy is still under observation. Macular vitreous warts Dry macular degeneration Exudative macular degeneration