If you notice pus flowing from a sore ear, you should first seek medical attention. The reasons for this are as follows: Earache and pus are symptoms. There are many diseases that also manifest as ear pain and pus, such as: cerumen embolism in the external ear canal, malignant tumors of the ear and specific infections of the ear, etc. Oral antibiotics for these diseases do not have any effect. Even if the ear pain and pus is caused by an infection, such as otitis media, oral antibiotics alone are not effective. Proper topical medication is crucial to treat otitis media. In view of the above reasons, please visit a hospital as soon as possible when you find ear pain and pus. Second-generation cephalosporins are usually chosen as the first choice of medication.