Prostacyclin can not be used by the elderly for a long time. Prostacyclin belongs to the topical use of estrogen, clinically commonly used in the treatment of perimenopausal after the menopause or menopausal elderly women, due to the decline in estrogen levels after the vaginal mucosal atrophy appeared senile vaginitis. By using estrogen topically, it can increase intravaginal secretions and relieve the symptoms of vaginal dryness and itching. Since Prostacyclin is essentially an estrogen, it is best not to use it for a long period of time to prevent the body from developing drug resistance and reducing the therapeutic effect of the drug. At the same time, long-term local use of estrogen is likely to lead to lesions in the epithelium of the vaginal mucosa, resulting in the emergence of new diseases, so long-term use of Prostacyclin is not recommended for the elderly. In conclusion, the elderly use of drugs, especially hormone drugs, before use, it is best to consult a professional doctor, combined with their own physical condition to choose individualized treatment plan.