Fishy odor coming up from the throat, considering the possibility of gastroesophageal reflux disease, it is recommended to improve the symptoms through general treatment and medication, the treatment should be carried out in accordance with the doctor’s instructions. 1. General treatment: It is recommended to have a light diet, avoid overfilling, stop smoking and drinking, have a regular work and rest schedule, and exercise reasonably to improve the symptoms. 2. Drug treatment: you can choose proton pump inhibitors such as omeprazole to inhibit the secretion of gastric acid; take drugs such as mosapride to promote gastrointestinal peristalsis; when inflammation occurs, you can take clindamycin, amoxicillin and other drugs to control inflammation. Due to individual differences, there is no absolute safest drug, it is recommended to strictly follow the doctor’s instructions to standardize the treatment.