You should never take amoxicillin after drinking alcohol: first of all, amoxicillin belongs to the penicillin class of drugs, which is already prone to allergic reactions. If you drink alcohol, it is easy to aggravate the allergic reaction, which can lead to very serious consequences and even death. Secondly, both alcohol and drugs are metabolized by the liver. If drinking alcohol is more damaging to the liver, amoxicillin will also be metabolized by the liver, so the double damage to the liver is more serious, so you should never take amoxicillin after drinking alcohol. Cephalosporin antibiotics can easily have a disulfiram-like reaction with alcohol, and penicillin drugs may also have a disulfiram-like reaction, which can be very dangerous and can lead to heart failure, myocardial infarction, or serious liver and kidney damage in more serious cases. Therefore, you should never take amoxicillin after drinking alcohol, and it is generally safer to wait 24 hours before taking amoxicillin.