The cause of breast swelling and pain should be clearly identified before determining which medication to take. Breast pain is commonly caused by physiological factors such as menstruation and pregnancy, as well as pathological factors such as breast hyperplasia, breast cancer, breast inflammation and trauma, which require different medications, so there is no most effective medication, but only the most suitable medication for the patient’s condition. 1. Physiological factors: most common in menstruation and pregnancy, the female body’s estrogen and progesterone levels change, which can lead to breast swelling, the patient with the end of menstruation, pregnancy, can gradually return to normal, do not need to carry out drug treatment, if the swelling is serious, you can give ibuprofen and other painkillers. 2. Pathological factors: breast hyperplasia can take drugs such as Tamoxifen. Breast cancer patients can also have breast swelling and pain, can be given ibuprofen and other pain relieving drugs, can also use tamoxifen and other endocrine drugs and lapatinib and other targeted drugs. Breast inflammation is mostly treated with appropriate antibiotics based on drug resistance. It is recommended that patients go to the hospital to improve the auxiliary examination to clarify the cause of the disease, and the drugs need to be used under the guidance of a professional physician.