Small pimples under the mouth may be caused by poor local cleansing, endocrine disorders or high sebum production. It can be removed by good cleaning, anti-androgen treatment or applying medication according to different situations. 1. Local cleaning is not in place: may be due to make-up after the lip cleaning is not thorough, blocked pores, resulting in sebum can not be discharged, thus forming acne. Usually need to pay attention to facial cleanliness and hygiene, you can use strong cleansing power of the cleansing milk to remove the local oil, so as to alleviate the symptoms. 2. Endocrine disorders: due to the patient’s endocrine disorders, thus causing androgen level abnormalities, resulting in excessive oil secretion around the mouth to block the pores. Anti-androgen treatment such as spironolactone or cyproterone can be given. 3. Excessive sebum secretion: when the sebum overflows, it is easy to cause skin acne, and may also appear pimples, pustules and other manifestations. At this time, you can apply retinoic acid cream, adapalene gel and other treatment, can effectively relieve the situation of acne under the mouth. If you have pimples under your mouth, avoid staying up all night, keep a happy mood, and go to the hospital in time for regular treatment under the guidance of a physician.