The normal value of prolactin is 1.61~18.77ng/ml, 48.72ng/ml is generally abnormal, belongs to the serious high, the common causes are pituitary disease, hypothyroidism, idiopathic hyperprolactinemia and other causes. 1. Pituitary disease: the more common is pituitary prolactinoma, generally are pituitary microadenomas, will cause serum prolactin increase. 2. Hypothyroidism: Primary hypothyroidism leads to an increased release of hormones, causing the pituitary gland to be stimulated to overproduce prolactin. 3. Idiopathic hyperprolactinemia: this disease also causes high serum prolactin, but usually without pituitary or central system disease. 4. Other causes: for example, cerebral diseases, craniopharyngeal tumors or lesions, can lead to prolactin secretion is affected, induced by high prolactin, polycystic ovary syndrome, traumatic factors, autoimmune diseases, and long-term use of antidepressant or antihypertensive drugs, can also cause prolactin elevation. It is recommended to go to the regular hospital to receive further examination, according to the results of the examination for treatment.