The corner of the mouth twitching may suggest many kinds of conditions, the specific analysis is as follows: 1, neurosis. Excessive mental tension or suffering from neuropsychiatric diseases, resulting in facial muscle twitching, the performance of the corners of the mouth twitching. Need to relax, active psychological treatment, if necessary, surgery. 2, facial spasm. The facial nerve abnormal discharge, will appear in the corners of the mouth, face and frontal muscles continue to contract, in fatigue and mental tension will aggravate, can be hot compresses, pay attention to warmth, do not catch cold, can be used phenytoin sodium or surgical treatment. 3, facial neuritis. Often seen in inflammation, fire, there will be facial numbness, the corners of the mouth twitching symptoms, you need to take oral anti-inflammatory drugs, while the hot compress. 4, facial nerve stimulation. For example, cold air causes the corners of the mouth to throb, pay attention to warmth, wear a mask, prevent cold, do not catch cold.