Silymarin does not generally harm the kidneys; on the contrary, studies have found that silymarin may have a protective effect on the kidneys. At present, the pharmacological effects of silymarin are found to include direct scavenging of reactive oxygen species, combating lipid peroxidation; protective effects on cell membranes, promoting the repair and regeneration of hepatocytes, and combating hepatic fibrosis; anticancer, radioprotection; lipid-lowering, and antiplatelet aggregation. In recent years, some studies have found that silymarin has a protective effect on nephrotoxicity caused by antitumor drugs and aminoglycosides, etc. When using the above drugs, the concomitant use of silymarin may prevent creatinine clearance from decreasing, reduce proteinuria and partially alleviate renal tubular damage. Silymarin is mainly used for the treatment of liver function abnormalities in acute and chronic hepatitis and fatty liver. It should be noted that it can not be used in patients with allergies, and should be adjusted by a doctor in time if there is no significant relief of symptoms after taking the drug. Its adverse reactions include nausea and chest tightness. For lactating women, children and other special groups of people using the drug is recommended to follow the doctor’s instructions. Silymarin has not been found to have damage to the kidneys, and its contraindications are not yet clear. If you need to use the above drugs need to be regulated under the guidance of a doctor to avoid adverse consequences.