Etiology: diabetic neuropathy; limb ischemia; limb infection. Examination: Neuropathy: Skin sensation can be examined by neurological methods such as using specially designed single stranded fibers weighing only 10g. The severity of neuropathy and the probability of susceptibility to ulceration can also be determined by composite examination scoring methods. Limb ischemia: Any diabetic foot ulcer that does not heal within two weeks of treatment requires a specialist examination by a vascular surgeon. Ankle-brachial index (ABI) testing; vascular ultrasound; X-ray digital subtraction angiography (DSA); CT angiography (CTA); magnetic resonance angiography (MRA). Infection: Clinical diagnosis of diabetic foot ulcer infection is based on 3 main criteria: purulent discharge from the ulcer wound; typical inflammatory manifestations around the ulcer such as redness, swelling, heat and pain; signs of systemic infection such as leukocytosis and fever. Treatment: General treatment: Reduce foot pressure, control diet and lower blood glucose; Local debridement: Debridement is the first step in the healing of diabetic ulcers, and the key to treatment is to remove non-viable infected tissue, including necrotic bone and hard calluses around the ulcer. After debridement, the wound surface is kept moist to facilitate rapid migration of epithelial cells to cover the wound surface and promote microvascular formation and connective tissue synthesis; anti-inflammatory treatment: appropriate antibiotics are selected according to the results of drug sensitivity test; arterial reconstruction: arterial bypass; minimally invasive treatment of lower limb vascular lumen. Interventional treatment: interventional treatment is one of the latest advances in vascular surgery, which is minimally invasive, safe and effective, including balloon dilation and stent implantation. Ultrasound ablation has been applied to patients with extensive and severe calcified occlusions. Others such as endovascular spinotomy and transcatheter direct perfusion thrombolysis have also been used in clinical practice. Autologous stem cell transplantation: It is one of the latest advances in the treatment of diabetic foot. The principle of autologous stem cell transplantation is to make use of the property that bone marrow stem cells can differentiate into vascular endothelial cells under certain induction conditions, and to implant autologous stem cells into the lesion to further differentiate and form new capillaries and promote the establishment of collateral circulation, so as to improve and restore blood flow in the lower limbs and treat lower limb ischemia. Chinese medicine evidence-based treatment: Diabetic foot belongs to the category of “pulse paralysis” and “gangrene” in Chinese medicine. According to clinical practice, we have divided diabetic foot into 5 types of treatment: ①Yin-cold type: treatment is to warm the meridians and disperse cold, invigorate the blood and open the veins, with the formula of Danggui Sihui Tang plus or minus; ②Blood stasis type: treatment is to invigorate the blood and resolve stasis, open the channels and relieve pain, with the formula of Dangshen Tongmai Tang plus or minus; ③Damp-heat infiltration type: treatment is to clear heat and relieve dampness, invigorate the blood and resolve stasis, with the formula of Si Miao Yongan Tang plus or minus; ④Heat-toxic incandescence type: treatment is to clear heat and resolve toxins, cool the blood and resolve stasis, with the formula of Si Miao Live Blood Tang The treatment is to warm the kidneys and strengthen the spleen, invigorate the blood and remove blood stasis, and the formula is based on tonifying the kidneys and invigorating the blood. The ideal goal of blood glucose control is glycosylated hemoglobin below 80 mg/L. Based on blood glucose control, the incidence of osteomyelitis can be reduced and the rate of amputation can be lowered by adopting evidence-based medicine and standardized comprehensive treatment for the causes of diabetic foot ulcers.