It is possible to get pregnant again if you have had a Down’s syndrome baby, but you need to do the relevant tests before and during pregnancy. Down’s syndrome is caused by abnormal cell division during the early stages of embryonic development and is mostly related to genetic factors, advanced maternal age and exposure to teratogenic factors during pregnancy. If there are chromosomal abnormalities in both parents, after carrying a Down’s child, the risk of Down’s syndrome in the fetus of another pregnancy is higher, and eugenic tests and chromosomal tests need to be done before pregnancy, and Down’s screening, NT tests, and amniocentesis can be done during pregnancy if necessary. If the mother is older, it is recommended to take folic acid from the first trimester to early pregnancy, which can prevent abnormal development of the fetal neural tube. If the pregnancy is caused by exposure to teratogenic factors during pregnancy, the woman should pay close attention to her surroundings when she is pregnant again to avoid exposure to such substances, which may cause abnormalities in the fetus. Therefore, women who have had Down’s syndrome babies can get pregnant again, but they need to do the relevant tests to avoid having Down’s syndrome babies again.