Eusemide is a combination of estrogen and progestin, but it does not increase estrogen in the body after taking it, mainly because the progestin used in Eusemide is drospirenone, which can counteract estrogen, so the application of Eusemide to regulate menstruation or contraception will not cause an increase in estrogen. For example, if you have uterine fibroids, if you have breast enlargement, tendency to thrombosis or high blood pressure, it is not recommended to take Eusebio orally, and you can use other methods of contraception or other methods of treatment. In addition, a small amount of vaginal bleeding may occur after taking Eusebio, but most of the bleeding will stop after continuing to take it.