Trisomy 21, also known as Down’s syndrome and also called congenital stupidity, is a genetic disorder caused by chromosomal abnormalities. Risk factors that lead to chromosomal variants are the mother being too old, over 40 years old, viral infections such as cytomegalic, rubella, herpes simplex, etc., especially if there are pets at home, it is easy to get infected. Then there are infections such as toxoplasmosis and syphilis that can cause chromosomal abnormalities, environmental pollution, radiation, etc. Women who have given birth to a Down’s child before are at an increased risk of becoming pregnant again. Once these factors are present, all of them need to be screened for high-risk groups.