Total occlusion of the distal ileo branch may cause angina pectoris, myocardial infarction, etc. It is recommended that the patient consult a doctor in time, and deal with the problem through general treatment, medication, and surgical treatment under the doctor’s guidance. 1. General treatment: patients with total occlusion of distal ileo branch can maintain a good state of body through reasonable diet, appropriate exercise, avoid overwork, etc., and improve the resistance of the body to help alleviate the symptoms. 2. Drug treatment: patients can follow the doctor’s instructions to apply drugs such as indobufen and cilostazol to prevent vascular obstruction; apply drugs such as alteplase and warfarin sodium to dissolve thrombus and anticoagulant in order to restore the normal flow of blood, thus relieving the symptoms. 3. Surgical treatment: patients can also take stent implantation under the guidance of the doctor, so that the distal total occlusion of the circumflex branch expansion, recirculation, in order to restore the normal blood supply to the heart, thereby relieving the symptoms. Patients with total occlusion of the distal ileocecal branch should go to the hospital in time and under the guidance of the doctor for the above examination and treatment.