Esophageal neurosis is mainly treated by general treatment, psychotherapy, taking drugs such as alprazolam, fluoxetine, omeprazole and so on. 1. General treatment: patients should pay attention to develop good habits of work and rest, ensure enough rest, avoid staying up late, and strengthen the exercise appropriately. At the same time, pay attention to diet, avoid eating cold, spicy and other stimulating food, so as not to aggravate the pharyngeal blockage, burning sensation and other uncomfortable symptoms. 2. Psychological treatment: the patient is due to long-term tension, mental stimulation and other psychosocial factors, and the emergence of mental disorders, usually there is no organic lesions, so psychological treatment is very important. Psychological counseling, self-relaxation training, and improvement of bad mood can be carried out to improve the patient’s symptoms. 3. Pharmacotherapy: It mainly includes anti-anxiety drugs such as diazepam and alprazolam, antidepressants such as fluoxetine and sertraline, and receptor-blocking drugs such as propranolol. If patients have severe symptoms such as foreign body sensation and heartburn in the throat, they can also take acid-suppressing drugs such as omeprazole and mucosal-protecting drugs such as bismuth potassium citrate to alleviate the symptoms. Patients with esophageal neurosis are advised to seek timely medical attention and actively receive treatment. Drugs are taken strictly in accordance with the doctor’s instructions, and should not be used on their own, so as not to delay or even aggravate the condition.