Closed mouth acne, mostly due to the blockage of pores, keratin and sebum congestion, resulting in the formation of the top white pimples, can be removed through general treatment, medication, physical therapy and other ways. 1. General treatment: patients should avoid eating high-fat, high-sugar food; pay attention to skin cleaning, it is recommended to use water or neutral soap to clean the face in order to reduce the oil clogging pores, try to avoid the use of oily cosmetics; avoid squeezing and scratching closed mouth acne, so as not to lead to pus inflammation. 2. Medication: Topical use of adapalene gel, tazarotene gel and other retinoids can help dissolve and expel acne; when accompanied by infection, benzoyl peroxide, azelaic acid and other medications can be used for topical application; if the acne develops to moderate or severe acne, minocycline, doxycycline, isotretinoin and other medications can be taken orally. 3. Physical therapy: when the effect of drug treatment is not good, you can carry out fruit acid peeling, red and blue light and other physical therapy; if necessary, you can be a professional medical personnel, using acne needles to pick it out, and at the same time need to carry out the anti-inflammatory treatment, to avoid self-operation. It is recommended that patients with closed mouth acne, through the general treatment is ineffective or aggravation of the condition, consult a doctor in a timely manner, under the guidance of the doctor’s standardized treatment, to avoid self-medication, in order to avoid delaying the condition.