Middle-aged and elderly nephrotic syndrome can usually be treated with hormones, but caution is needed. Nephrotic syndrome can be selected according to different pathological types using glucocorticoids, such as prednisone acetate, etc., and/or immunosuppressant therapy, such as cyclophosphamide, tacrolimus, etc., but need to consider the patient’s age, complications and adverse drug reactions, etc., due to the hormones often cause osteoporosis, femoral head necrosis, etc., middle-aged and elderly nephrotic syndrome, the use of hormones need to be cautious. For patients with contraindications, you can choose to use renin-angiotensin-aldosterone receptor antagonists (valsartan, Benadryl, etc.), use immunosuppressants such as tacrolimus alone, or choose rituximab. It is recommended that middle-aged and old-aged nephrotic syndrome should be combined with clinical symptoms, pathologic typing rational choice of drugs. Specific medication should be completed under the guidance of specialists, and should not be used without authorization to avoid aggravating the condition. It is recommended that middle-aged and elderly patients with nephrotic syndrome should go to regular hospitals in time and standardize the treatment under the guidance of physicians.