Amoxicillin is an anti-inflammatory drug that can easily lead to allergic reactions and drug dermatitis in the organism. In clinical treatment, oral amoxicillin should be prohibited, while different treatments should be chosen according to the severity of the disease. If the peripheral rash is dense, accompanied by intense itching as well as the manifestation of generalized hyperthermia, it is necessary to order compound glycyrrhizic acid monoammonium S sodium chloride injection. If accompanied by systemic manifestations such as high fever and chills, intramuscular injection of compound betamethasone is needed to enhance anti-allergic and immunosuppressive treatment. Oral levocetirizine hydrochloride oral solution and olopatadine hydrochloride tablets and topical application of furnace glycolic lotion are also required. If the high fever persists you can take oral ibuprofen suspension for symptomatic antipyretic treatment, and the patient is advised to drink more water.