Hypertrophy of the limbs is usually caused by excessive secretion of growth hormone (GH) by the pituitary gland. In adolescents, gigantism is formed when the epiphysis is not closed; in adolescents, the epiphysis has fused and acromegaly is formed; in a few cases, the disease starts in adolescence and continues to develop in adulthood to form acromegaly gigantism. So, how should hypertrophy of the limbs be diagnosed? The following is a brief introduction: 1. The face is typical of acromegaly, with hypertrophy of the hands and feet, enlarged head, thickened lips, low tone, protrusion of the lower jaw and sparse teeth, and other clinical manifestations of acromegaly. 2. Endocrinological and biochemical examinations may reveal elevated plasma GH concentration, mostly above 10ng/ml, and may be accompanied by elevated PRL, elevated blood glucose, elevated blood phosphorus, abnormal thyroid function and abnormal bone metabolism indexes. In the oral glucose tolerance test, a hyperglycemic curve can be observed, while the plasma GH level cannot be suppressed, and the GH is mostly above 5ng/ml. In the TRH excitation test, the plasma GH value is greater than 50% of the basal GH value, while the GH value is mostly above 10ng/ml. At the same time, SMc and IGF-workers may be significantly increased. 3.X-ray and CT scan examination can find the enlargement of butterfly saddle, saddle area occupying lesion, peri-saddle compression, hand and foot enlargement and widening, skull, long bone and spine bone and other X-ray specific performance, which can assist in the diagnosis. 4, special tests of bone such as single photon or two-photon bone densitometry, and QCT determination of BMC content, etc., can detect abnormal manifestations such as osteoporosis and/or osteopenia. the QCT measurement value reflects, the credibility of the actual bone mineral content, CT value and bone calcium content are closely related, mostly the third lumbar vertebra is the measurement site. the QCI determination of vertebral BMC can have four applications, namely: ① evaluation of (1) to evaluate the effect of various hormone levels on bone metabolism; (2) to evaluate and determine the loss of bone associated with normal age; (3) to determine the fracture risk threshold and fracture threshold; and (4) to evaluate the effect of various drugs and exercise programs on BMC.