The acute stage of massive cerebral infarction refers to within 2 weeks of the onset of the disease, and massive cerebral infarction has a more rapid onset and the patient’s condition is more serious. At the initial stage, preliminary judgment can be made according to the degree of limb paralysis and the gaze of both eyes to the opposite side of the lesion, and then improve the CT examination of the head. Excluding cerebral hemorrhage, if the patient’s onset time is within 6 hours, there is no contraindication to thrombolysis, and the family agrees to thrombolysis, the patient can be given rt-PA for intravenous thrombolysis. If the thrombus blocked in the blood vessel can be dissolved, the patient’s symptoms of cerebral neurological deficit will be mostly recovered, even without any sequelae. If the patient’s visit to the clinic has lasted for more than 6 hours, it is necessary to determine the cause of the patient’s morbidity. If it is caused by atrial fibrillation or embolus dislodgement, the patient should be given anticoagulant drugs for treatment, and if the patient’s fibrinogen level is relatively high, he should be given bacitracin sedation to reduce the fibrinogen in the blood. Through the above active treatment, the patient’s symptoms of massive cerebral infarction can also be partially recovered. However, it should be noted that during massive cerebral infarction, more serious cerebral edema will appear in 2-3 days after the onset of the disease, in this case, in order to prevent the patient from developing cerebral hernia, we need to give dehydration, lowering cranial pressure medication. At the same time, it is necessary to prevent complications after massive cerebral infarction, mainly including pulmonary infection and gastrointestinal bleeding.