Perianal ulcers with what drugs should be based on the diseases that cause perianal ulcers to decide, can be divided into three cases: 1, perianal abscess, for the rectum perianal space of acute purulent infection. When the abscess rupture caused by perianal skin ulcerative changes, should be given cephalosporin anti-infective treatment and active surgical incision and drainage.2, hemorrhoids, when hemorrhoids repeatedly prolapse, intestinal fluid persistent stimulation of perianal skin, can lead to perianal skin chronic inflammatory changes, when severe, chronic ulcers can be formed. At this time can be given iodine povidone disinfection of the skin around the ulcer, and apply erythromycin ointment, 1:5000 potassium permanganate sitz bath, anus local application of hemorrhoidal ointment and other treatments for ulcers can be healed.3, anal fistula, often secondary to the perianal abscess breakout or incision and drainage, stool through the external mouth penetration to the perianal skin, causing perianal skin ulceration to form ulcers, once diagnosed, should be immediately performed surgical treatment.