White spots on the legs of pregnant women can be considered related to vitiligo, anemic nevi or post-inflammatory hypopigmentation and other diseases. 1. vitiligo: pregnant women can be due to autoimmune reactions, oxidative stress and other etiological factors lead to skin pigmentation loss, this time in the exposed, friction parts or all over the body of the pigmentation loss of varying sizes, white spots can be generalized, mono, or dissemination, lesions of varying sizes, so it can be a white spot, often without conscious symptoms. 2. Anemic nevus: the developmental defects and functional abnormalities of vascular tissues, can develop in adulthood, appearing as pale spots of different sizes, and the skin around the white spots can turn red after friction. 3. Post-inflammatory hypopigmentation: there is often a history of primary disease, such as psoriasis, dermatitis, eczema, etc., and there is hypopigmentation at the local lesions, so white spots can be seen. Pregnant women with white spots on their legs should seek medical attention in time, observe the changes in white spots and the presence of other skin lesions, and follow the doctor’s instructions to standardize and rationalize the use of medication after the etiology is clear.