There are many causes of hand and foot soreness, which are common in the following diseases: first, consider arthritis, especially rheumatoid arthritis, patients will occur in the whole body small joint pain and swelling. The main feature of rheumatoid arthritis is bilateral symmetrical joint swelling, which can occur in the proximal interphalangeal joints, metacarpophalangeal joints, wrist joints, metatarsophalangeal joints and so on, and the patients will show soreness in the joints of hands and feet. Secondly, degenerative osteoarthritis is considered, which is mainly manifested as joint degeneration, cartilage wear and tear, joint osteophytes, and in the old people, there is often pain in single joints of the hands and single joints of the feet, which is mostly caused by degenerative osteoarthritis. Thirdly, it is considered to be caused by high fever. When the basic metabolic rate is accelerated during fever, glycolysis is accelerated, and lactic acid will accumulate in the joints and muscles all over the body, which will cause the patient’s hands and feet to be sore and the whole body to be sore and painful.